Phosphatidylserine is a type of phospholipid that plays a crucial role in cell membrane composition, particularly in brain cells. It’s essential for neurotransmission, maintaining cell membrane fluidity, and overall brain function. Recently, phosphatidylserine has gained attention as a key ingredient in memory supplements, often combined with other supplements like policosanol. While our bodies naturally produce phosphatidylserine, production decreases with age, potentially necessitating supplementation.
The rising popularity of phosphatidylserine in memory supplements stems from research suggesting its effectiveness in enhancing cognitive function, particularly memory, and potentially preventing dementia. This makes it an attractive option for middle-aged and older adults looking to maintain cognitive health. As we age and naturally experience memory decline, phosphatidylserine-based memory supplements may help preserve cognitive function and potentially prevent neurodegenerative conditions like Alzheimer’s disease.
Phosphatidylserine is widely used in dietary supplements and has received recognition from both the U.S. Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA). As a crucial component for brain health, this ingredient in memory supplements can benefit not only older adults experiencing memory decline but also younger individuals dealing with high stress levels. Phosphatidylserine has thus become a cornerstone in many memory supplements, offering more than just nutritional support.

How Phosphatidylserine Works in the Body
Phosphatidylserine, a common ingredient in memory supplements, plays several vital roles in our physiology. It’s essential for maintaining cell membrane fluidity, which is crucial for efficient neurotransmission – a process directly linked to memory and cognitive function. When phosphatidylserine levels are sufficient, cell membranes remain flexible, allowing for more effective movement of neurotransmitters.
Additionally, phosphatidylserine helps regulate stress hormones like cortisol. High cortisol levels can impair cognitive function, but phosphatidylserine in memory supplements may help suppress these levels, contributing to better brain health. This stress-reducing effect can help maintain memory and concentration even in high-stress situations.
Lastly, phosphatidylserine influences synaptic plasticity, which is vital for learning and memory formation. This ability to enhance the brain’s capacity to form and retain new memories is one of the key reasons why phosphatidylserine is so valued in memory supplements.

Pros and Cons of Taking Phosphatidylserine Memory Supplements
When considering phosphatidylserine memory supplements, it’s important to weigh the pros and cons. On the positive side, numerous studies have shown that these memory supplements can improve brain function, enhancing memory and cognitive abilities. They may also help lower cortisol levels, potentially preventing stress-induced memory decline.
However, there are some drawbacks to consider. Some individuals may experience side effects such as digestive issues, sleep disturbances, or headaches when taking phosphatidylserine memory supplements. Moreover, long-term use of high doses could potentially have adverse effects and disrupt the body’s phospholipid balance. It’s crucial to adhere to recommended dosages when using these memory supplements.
Caution is advised for individuals taking blood thinners or antidepressants; they should consult a healthcare professional before starting phosphatidylserine memory supplements. Pregnant or breastfeeding women should also avoid these supplements or seek medical advice before use.

FDA Guidelines for Phosphatidylserine Memory Supplements
The U.S. Food and Drug Administration (FDA) has provided guidelines for the use of phosphatidylserine in memory supplements. While phosphatidylserine is most commonly consumed in supplement form, dosage is crucial. For adults, the FDA suggests a daily intake of 100-300mg of phosphatidylserine in memory supplements. It’s advisable not to exceed this range.
The FDA also emphasizes caution when combining phosphatidylserine memory supplements with other supplements. Particularly, when taking phosphatidylserine alongside other ingredients that may affect blood circulation, like policosanol, it’s important to adjust dosages and timing of intake.
Lastly, while the FDA considers phosphatidylserine safe as a dietary supplement, they recommend consulting a healthcare professional before taking these memory supplements if you have chronic health conditions or are on specific medications. This is especially important for those experiencing significant memory decline, as professional evaluation is crucial in such cases.

Research on Phosphatidylserine Memory Supplements
Several studies have explored the effects of phosphatidylserine memory supplements on cognitive function and dementia prevention:
- “Cognitive improvement by phosphatidylserine-containing supplement in elderly Japanese subjects with memory complaints” – This study found that those taking phosphatidylserine-containing supplement showed significant improvements in memory and learning abilities. After 12 weeks, short-term memory tests improved by over 20%.
- “Phosphatidylserine and cognitive decline in the elderly” – This research suggested that phosphatidylserine might help suppress early symptoms of dementia, including Alzheimer’s disease. The group taking these supplements showed slower neural degeneration and higher scores on memory tests.
- “Effects of phosphatidylserine on cognitive performance and mood in the elderly” – This study demonstrated that phosphatidylserine not only improved memory but also enhanced overall cognitive performance and mood. Participants showed improved concentration and working memory after 8 weeks of supplementation.
- “Phosphatidylserine and its effect on Alzheimer’s disease” – This research revealed that those taking phosphatidylserine experienced slower cognitive decline compared to a placebo group, with significant improvements in verbal memory.
- “The role of phosphatidylserine in the treatment of age-related cognitive decline” – This study highlighted the effectiveness of phosphatidylserine in slowing age-related cognitive deterioration. The researchers concluded that these supplements could play a crucial role in preserving memory and potentially preventing dementia in older adults.
